Advantages of spray drying

Advantages and disadvantages of spray dryer Practice has shown that spray drying is currently a very important industrial drying. It is widely used for industrial purposes in almost all sectors of the national economy.

Spray drying is a drying method described more than 140 years ago to improve the drying and compaction of liquids. But the complexity and knowledge of this process made it possible to use it industrially only at the beginning of the 20th century. Milk powder production was the first commercial application and is still one of the most important applications of this technology.

Spray drying involves atomizing liquid materials into

Very fine droplets in a hot gas dryer and separating the particles from the dried gas with a wheel and/or filter bag as a powdered end product. The raw material can be a solution, suspension or emulsion, and the final product can be characterized as a powder, granules or agglomerates.

Thus, in a continuous process, spray drying turns the liquid feed into a powder with well-defined properties. Properties such as moisture content or residual solvent in the powder, particle morphology or powder size and density are largely adjustable to the desired level. The remarkable flexibility, slowness and economy of the final powder production characteristics compared to competing technologies such as freeze-drying have made it widespread in many industries, including cosmetics, fine chemicals, detergents, polymers, fillers and pharmaceuticals.

1. Increased bioavailability

Many modern therapeutic compounds are stable in crystalline form, but often insoluble in water, resulting in slow dissolution rates. This reduces the bioavailability of the API, sometimes to the point of losing the therapeutic effect.

By drying, the API can be precipitated together with the polymer into a stable amorphous solid dispersion, thereby greatly improving the dissolution rate. In particular, the unprecedented drying speed allows the API to be preserved in an amorphous form.

An interesting method to increase the dissolution rate is to break the nanoparticles into larger constituents and then reconstitute them using a spray drying process. By improving the dissolution rate in this way, aerosol drying can be used to achieve potential treatments that are currently impractical due to low bioavailability.

First, the benefits of spray drying.

1, the drying conditions are kept constant and the dry product consumption remains the same.

2, the spray drying process is continuous, the system can be a fully automatic control process.

3, the spray drying system is suitable for heat-sensitive and non-drying heat-sensitive materials with good water and organic solvents for drying materials.

4, liquid raw materials can be solution, suspension, emulsion, paste or melt, cake, etc.

5, Spray drying with high flexibility. The spraying capacity is 1000-200 grams per hour.

Second, the lack of spray drying

1, investment costs are high.

2 refers to the drying convection dryer, the thermal efficiency is relatively low, usually 30% to 40%. For more information visit our website Spin flash dryer.