10 Factors to Consider When Selecting a Mass Spectrometry Service Company for Drug Development

Mass spectrometry testing services are one of the most vital quantitative and qualitative assessments. With more advanced instrumentation being launched, mass spectrometers are evolving with a spectrum of bioanalytical applications. Today mass spectrometry laboratories have numerous options of mass spectrometers to choose from. Depending on a specific mass spec service, a unique mass spectrometer can be assigned to handle specific analytic applications. Besides, hyphenated techniques such as GC-MS and LC-MS bioanalysis have further increased the importance of mass spectrometry service companies. However, finding an ideal mass spectrometry service company can be challenging. Hence the current article shares ten factors sponsors should consider when selecting mass spectrometry testing services for drug development.

Identifying the intended applications of mass spectrometry analysis

Sponsors generally have an idea of the analyte of interest. Today mass spectrometers can measure analytes in a wide range of study materials. Besides, each of these mass spectrometers has unique advantages and limitations. It is crucial that an ideal mass spectrometry laboratory understands your intended applications and provides solutions accordingly. 

Can the mass spectrometry laboratory handle additional specifications?

Drug development studies are an ever-evolving domain. Analyzing compounds using mass spectrometers often requires a supplementary instrument to separate and purify the sample, for example, gas chromatography and liquid chromatography. Ensure that the lab is efficient in coping with these additional specifications. 

Evaluate additional services

Identifying whether a particular laboratory has the required mass spectrometer instrument is crucial. However, that’s not the only decision-making when deciding on an ideal mass spectrometer laboratory. Identify whether the laboratory offers additional accessories, information, and services about mass spectrometers. 

Can the laboratory deal with extensive mass spectrometer information

Before beginning any bioanalysis, determine whether the mass spectrometer laboratory can handle large amounts of study data. Some laboratories specialize in generating specific types of data. Hence identify whether their expertise aligns with your expectations. 

Think one step ahead

The primary reason to outsource MS analysis is due to the lack of instrumentation and expertise available in-house. However, ensure that an ideal laboratory can offer support and expertise while partnering with additional laboratories, for example, a laboratory conducting clinical research. 

Understanding laboratory capacity

Identify whether the laboratory can handle additional bioanalysis. Drug development is an ever-evolving space where each step of drug development may need additional bioanalysis. 

Your budget

Budget is often the primary concern when outsourcing bioanalytical studies. Although identifying mass spectrometry laboratories depends on their expertise, ensure their services are within your budget. 

Direct separation MS analysis

Online separation with MS units can help accelerate the experimental timelines. Identify laboratories that can employ such direct sample introduction methods while analyzing complex study samples. 

Sample handling, collection, and storage

Several variables can influence drug development analysis. These variables are introduced generally during the handling, collection, and storage of study samples. Thus it is vital to confirm whether mass spectrometer laboratories have systems to reduce these preanalytical variables. 

Power Analysis

The number of study participants and associated biological samples relies on the study design. However, reliable results depend on the power analysis of a specific study. Hence, identify laboratories that can offer appropriate power analysis during bioanalytical experiments.